By E. Díaz-Rubio, H.-J. Schmoll
Complement factor: Oncology 2005, Vol. sixty nine, Suppl. three
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Additional info for Critical Role of Anti-angiogenesis And Vegf Inhibition in Colorectal Cancer (Supplement Issue: Oncology 2005)
Information from the phase III trial of bevacizumab in metastatic CRC suggests that patients at risk of arterial thromboembolic events who receive bevacizumab can beneﬁt from therapy . Patients who developed venous thromboembolism were managed using full-dose anticoagulation, as described below . 2 vs. 61) despite the increased risk of arterial thromboembolism . Furthermore, Hambleton et al.  analyzed hemorrhagic complications in patients in the phase III study who received anticoagulant therapy (full-dose warfarin) for thrombotic events, and found no evidence for any increase in these complications for patients in the bevacizumab arm (table 4).
26 Schleucher N, Trarbach T, Junker U, Tewes M, Masson E, Lebwohl D, Seeber S, Laurent D, Vanhoefer U: Phase I/II study of PTK787/ ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor in combination with FOLFIRI as ﬁrst-line treatment for patients with metastatic colorectal cancer. J Clin Oncol 2004;22(suppl): abstract 3558. 27 Roche: Avastin Summary of Product Characteristics. 2005. 28 Lee A: Epidemiology and management of venous thromboembolism in patients with cancer. Thromb Res 2003;110:167–172.
30 Skillings JR, Johnson DH, Miller K, Kabbinavar F, Bergsland E, Holmgren E, Holden SN, Hurwitz H, Scappaticci F: Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy. J Clin Oncol 2005; 23(suppl):196s (abstract 3019). 31 Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L, Dickler M, Overmoyer BA, Reimann JD, Sing AP, Langmuir V, Rugo HS: Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer.
Critical Role of Anti-angiogenesis And Vegf Inhibition in Colorectal Cancer (Supplement Issue: Oncology 2005) by E. Díaz-Rubio, H.-J. Schmoll