By Joan Fujimura
in the course of the overdue Nineteen Seventies and Nineteen Eighties, "cancer" underwent a extraordinary transformation. in a single brief decade, what had lengthy been a suite of heterogeneous ailments marked via out of control cellphone development grew to become a affliction of our genes. How this occurred and what it capacity is the tale Joan Fujimura tells in a unprecedented within examine the way in which technology works and data is created. A dramatic examine of a brand new species of medical revolution, this booklet combines a close ethnography of clinical notion, an in-depth account of technology practiced and produced, a heritage of 1 department of technological know-how because it entered the limelight, and a view of the influence of latest genetic applied sciences on technology and society.
The medical company that Fujimura unfolds for us is proto-oncogene melanoma research--the learn of these segments of DNA now proposal to make general cells cancerous. inside this framework, she describes the procedures of information development as a social firm, an unending sequence of negotiations during which theories, fabric applied sciences, and practices are co-constructed, included, and refashioned. alongside the way in which, Fujimura addresses long-standing questions within the background and philosophy of technological know-how, tradition concept, and sociology of technology: How do scientists create "good" difficulties, experiments, and strategies? What are the cultural, institutional, and fabric applied sciences that experience to be in position for brand spanking new truths and new practices to prevail?
Portraying the advance of data as a multidimensional strategy carried out via a number of cultures, associations, actors, gadgets, and practices, this booklet disrupts divisions between sociology, historical past, anthropology, and the philosophy of technological know-how, expertise, and drugs.
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Additional info for Crafting Science: A Sociohistory of the Quest for the Genetics of Cancer
In the process of transplanting tumors, tumor biologists noticed that rat and mouse tumors could be successfully transplanted into rats and mice of the same strains but could not be successfully transplanted to animals from other strains. Neither did human tumors survive in animals. Between the 1 9 2 0 s and 1940s, some researchers took note of these observations and began to develop colonies of inbred strains of mice (later expanded to rats and guinea pigs) as their primary research tools for studying, among other things, the genetics of cancer.
Limitations, cell culture had for many years relatively little general impact, and was regarded more as an art than as a basic research tool in biology and medicine. . This evaluation has changed in recent years as a result of discoveries that make clear the potential of isolated cell systems for the analysis of problems in experimental morphogenesis, cytogenetic variation, cell-virus relationships, and many other types of investigations. A rapid evolution in technology has occurred, which greatly enhanced the usefulness of cell cultures in experimental research designs.
Second, they established large volumes of tumors that were later used in biochemical studies. Third, they constructed experimental animal strains. Rodents became a popular tool for transplantation research in the twentieth century. Inbred strains of mice were perhaps the most important tool developed during this time for subsequent cancer and noncancer biological research. In the process of transplanting tumors, tumor biologists noticed that rat and mouse tumors could be successfully transplanted into rats and mice of the same strains but could not be successfully transplanted to animals from other strains.
Crafting Science: A Sociohistory of the Quest for the Genetics of Cancer by Joan Fujimura