Get Clinical Radiation Oncology: Expert Consult - Online and PDF

By Leonard L. Gunderson MD MS FASTRO, Joel E. Tepper MD

ISBN-10: 1437716377

ISBN-13: 9781437716375

First Prize winner, Oncology e-book type, British clinical organization 2012 scientific publication Competition

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Extra resources for Clinical Radiation Oncology: Expert Consult - Online and Print, 3e

Sample text

With the advent of mam­ malian cell culture and synchronization techniques and timelapse cinemicrography, it became possible for investigators to study mitotic and division delay phenomena in greater detail. Mitotic delay, defined as a delay in the entry of cells into mitosis, is a consequence of “upstream” blocks or delays in the movement of cells from one cell cycle phase to the next. Division delay, a delay in the time of appearance of new cells at the completion of mitosis, is caused by the combined effects of mitotic delay and any further lengthening of the mitosis process itself.

By studying histologic sections of a human bronchial car­ cinoma, Thomlinson and Gray105 noted that necrosis was Figure 1-20 Cell survival curve for a murine lymphosarcoma growing subcutaneously and irradiated in vivo. The biphasic curve suggests the presence of a small but relatively radioresistant subpopulation of cells, determined in accompanying experiments to represent the tumor’s clonogenic hypoxic fraction. Adapted from Powers WE, Tolmach LJ: A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated.

5% oxygen, more than a factor of 10 lower than partial pressures of oxygen usually encountered in normal tissues. 5% has been termed oxygen’s “k-value” and is obtained from an oxygen “k-curve” of relative radiosensitivity plotted as a function of oxygen tension112 (Fig. 1-23). 5 Gy) 14 16 18 20 Figure 1-21 Representative survival curves for cells irradiated with x rays in the presence (aerobic) or virtual absence (hypoxic) of oxygen. 05. DNA-sensitizer • Figure 1-22 Schematic representation of the proposed mechanism of action for the oxygen effect.

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Clinical Radiation Oncology: Expert Consult - Online and Print, 3e by Leonard L. Gunderson MD MS FASTRO, Joel E. Tepper MD


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