By Abraham, Jame; Allegra, Carmen J.; Gulley, James L
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Additional info for Clinical Oncology
Thus far, trials of targeted agents have not developed a clear signal of which salivary tumors may respond to a particular targeted therapy, even when the target is present. Targeted therapies, particularly inhibitors of EGFR, VEGF or its receptors, and Her-2/ neu, have been tested in phase 2 clinical trials. Larger trials or trials incorporating molecular eligibility criteria are needed to confirm the activity of these new agents against salivary gland cancers either alone, or in combination. Exploratory studies of assigning treatments based on molecular abnormalities of a particular patient’s tumor have shown intriguing results (response or prolonged time to progression).
Sentinel lymph node dissection requires expertise due to the complexity of lymph drainage in the head/neck region, and the possibility of sentinel nodes in the parotid gland, with risk of facial nerve injury on dissection. Mucosal melanomas represent less than 1% of all melanomas. The peak age of diagnosis is 60 to 80 years. In SEER data from 1987 to 2009, 452 mucosal melanomas of the head and neck were reported. The majority occurred in the nasal cavity, paranasal sinuses and middle ear (73%), while fewer occurred in the oral cavity, oropharynx, NP, or salivary gland (27%).
Fury MG, Pfister DG. Current recommendations for systemic therapy of recurrent and/or metastatic head and neck squamous cell cancer. J Natl Compr Canc Netw. 2011;9:681-689. 11. Langendijk JA, Bourhis J. Reirradiation in squamous cell head and neck cancer: recent developments and future directions. Curr Opin Oncol. 2007;19:202-209. 12. Laurie SA, Ho AL, Fury MG, Sherman E, Pfister DG. Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review.
Clinical Oncology by Abraham, Jame; Allegra, Carmen J.; Gulley, James L