Download e-book for iPad: Cellular Senescence and Tumor Suppression by Peter D. Adams, John M. Sedivy

By Peter D. Adams, John M. Sedivy

ISBN-10: 1441910743

ISBN-13: 9781441910745

As cells mature they evidently cease dividing and input a interval known as senescence. yet mobile senescence is usually prompted upfront via yes oncogenes keen on melanoma improvement. mobile senescence, a growth-arrest application that limits the lifespan of mammalian cells and forestalls limitless telephone proliferation, is attracting substantial curiosity due to its hyperlinks to tumor suppression.

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Preparation of Cytologic Specimens Cytologic specimens prepared during intraoperative consultation can be very helpful. The cytologic preparation, which uses fixation in 95% ethanol, yields exquisite cytoplasmic and nuclear detail that is free of the distortion produced by freezing. One of 4 cytologic preparation techniques can be used, depending on the type and consistency of the tumor (Table 2–2). For a suspected pituitary adenoma, the procedure of choice is always the touch (also called imprint) preparation.

Studies of the effects of SV40-contaminated polio vaccine on cancer incidence have found unconvincing results of an association with brain tumors. With regard to the varicella-zoster virus, the agent for chickenpox and shingles, 1 study found that more mothers of children with medulloblastomas than control mothers were exposed to chickenpox during pregnancy, while another study did not. Other research showed that adults with gliomas in the San Francisco Bay area were significantly less likely than control subjects to report having had either chickenpox or shingles.

48 Catheter Angiography ................................................................................................. 50 Key Practice Points ....................................................................................................... 51 Suggested Readings ...................................................................................................... 51 CHAPTER OVERVIEW This chapter provides the practicing oncologist with a basic understanding of the current and rapidly evolving technologies used at M.

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Cellular Senescence and Tumor Suppression by Peter D. Adams, John M. Sedivy


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