By Charles S. Cleeland, Michael J. Fisch, Adrian J. Dunn
Melanoma Symptom technology is the 1st interdisciplinary compilation of analysis at the mechanisms underlying the expression of cancer-related signs. It offers suggestions in scientific, animal and in vitro learn, examine equipment in mind imaging, and statistical-descriptive techniques to figuring out the mechanistic foundation of symptom expression. This quantity additionally presents views from sufferers, govt and undefined. by way of gathering and synthesizing the constructing threads of recent methods to knowing cancer-related signs, the e-book promotes a pioneering framework for merging behavioral and organic disciplines to elucidate mechanisms of symptom evolution, incorporating new applied sciences, checking out novel brokers for symptom keep watch over, and enhancing sufferer functioning and caliber of existence either in the course of and after melanoma therapy. With knowledgeable editorial group led by way of Charles S. Cleeland, an internationally-recognized chief in melanoma soreness evaluate and therapy, this can be crucial interpreting for surgical, medical and scientific oncologists, educational researchers, and pharmaceutical businesses constructing new brokers to regulate symptom expression
Preface; Foreword; half I. creation: 1. creation to melanoma Symptom technological know-how Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; 2. getting to know the mechanisms underlying the indications of sufferers with melanoma Adrian J. Dunn; three. Cytokines, disorder habit: a version for melanoma indicators Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla and Allan Siegal; half II. melanoma Symptom Mechanisms and versions: scientific and simple technological know-how: four. The scientific technological know-how of melanoma ache review and administration Russell ok. Portenoy and Victor T. Chang; five. discomfort: uncomplicated technological know-how: 5a. Mechanisms of disease-related discomfort in melanoma: insights from the research of bone tumors Patrick W. Mantyh and Juan Miguel Jimenez Andrade; 5b. Neuropathic discomfort: simple technology Patrick M. Dougherty and Haijun Zhang; 6. Cognitive disorder: is chemobrain actual? Christina A. Meyers and Jeffrey S. Wefel; 7. Cognitive impairment: simple technological know-how Perry N. Fuchs, Jessica A. Boyette-Davis and Adrian J. Dunn; eight. melancholy in melanoma: pathophysiology on the mind-body interface Andrew H. Miller, Michael A. Burke and Charles L. Raison; nine. Depressive ailment: easy technological know-how: 9a. Animal versions of depressed temper and illness habit Adrian J. Dunn; 9b. From irritation to illness and melancholy: the cytokine connection Robert Dantzer and Keith W. Kelly; 10. Cancer-related fatigue: medical technology Xin Shelley Wang; eleven. constructing translational animal types of cancer-related fatigue Mary W. Meagher; 12. melanoma anorexia/weight loss syndrome Aminah Jatoi and Nisha Lassi; thirteen. urge for food loss/cachexia: easy technology Tristin D. Brisbois-Clarkson, Wendy V. Wismer and Vickie E. Baracos; 14. Sleep and its problems: medical technological know-how Sofia Ancoli-Israel and Lianqi Liu; 15. Sleep and its problems Mark R. Opp and Luca Imeri; sixteen. Proteins and signs Bang-Ning Lee and James M. Reuben; 17. Genetic techniques to treating and combating signs in sufferers with melanoma Quiling Shi and Charles S. Cleeland; 18. sensible imaging of indicators T. Dorina Papageorgiou, Edward F. Jackson and Javier O. Valenzuela; 19. High-dose treatment and posttransplantation symptom burden: impressive a stability Sergio A. Giralt and Loretta A. Williams; half III. scientific views in Symptom administration and study: 20. selling symptom examine in cooperative teams Lynne I. Wagner and David Cella; 21. useful facets of symptom administration in sufferers with melanoma Richard T. Lee and Michael J. Fisch; half IV. Symptom dimension: 22. Symptom dimension by means of sufferer file Charles S. Cleeland and Tito R. Mendoza; 23. The economics of cancer-related indicators: valuing supportive care interventions Lesley-Ann Miller and Jane C. Weeks; 24. Longitudinal types for indicators Diane L. Fairclough; 25. Bayesian adaptive layout: a brand new method of attempt the effectiveness of symptom-reducing brokers utilizing patient-reported results Valen E. Johnson and Tito R. Mendoza; half V. executive and views: 26. selling melanoma symptom technology study Ann O'Mara and Maria Sgambati; 27. constructing symptom administration medications Joanna M. Brell and Lori M. Minasian; 28. Cancer-related signs: concerns for attention in drug and healing organic product label claims within the usa Jane A. Scott; 29. Symptom study: taking a look forward Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; Index
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Additional info for Cancer Symptom Science : Measurement, Mechanisms, and Management
63. Deimling GT, Kahana B, Bowman KF, Schaefer ML. Cancer survivorship and psychological distress in later life. Psychooncology 11(6):479–494, 2002. 64. McHutchison JG, Gordon SC, Schiff ER, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 339(21):1485–1492, 1998. 52. Miguelez M, Lacasse M, Kentner AC, Rizk I, Fouriezos G, Bielajew C. Short- and long-term effects of interleukin-2 on weight, food intake, and hedonic mechanisms in the rat.
75,76 In C57Bl/6J mice, this effect is paralleled by elevations in brain IL-1β and TNF-α mRNA. 76 Fatigue is also linked with Epstein-Barr virus (EBV). 77 Molecular mechanisms Proinflammatory cytokines are capable of inducing various symptoms of sickness behavior. However, certain cancer-related symptoms that are likewise characteristic of sickness behavior are induced by different cytokine-neurotransmitter mechanisms. 4 offered an intriguing unifying hypothesis: that nuclear factor κB (NF-κB), a transcription factor that regulates innate and adaptive immune responses, plays a fundamental role in underlying these behavioral alterations.
Nonetheless, these studies underscore the need to identify molecular mechanisms and could have important implications in the development of treatments for cancer-related symptoms. Conclusion Behavioral changes that are characteristic of sickness behavior are mediated by the individual or combined actions of proinflammatory cytokines via cytokine neurotransmitter receptor and molecular mechanisms. In light of the striking similarity between sick- 13 Introduction – Section 1 ness-related and cancer-related symptoms, it may be suggested that they are mediated by common cytokinergic mechanisms.
Cancer Symptom Science : Measurement, Mechanisms, and Management by Charles S. Cleeland, Michael J. Fisch, Adrian J. Dunn