Read e-book online Cancer Biomarkers in Body Fluids: Biomarkers in Circulation PDF

By Gabriel D. Dakubo

ISBN-10: 3319483595

ISBN-13: 9783319483597

ISBN-10: 3319483609

ISBN-13: 9783319483603

This ebook examines intensive the facts, scientific purposes and power melanoma signatures within the flow and discusses changes in circulating cell-free nucleic acids, and circulating tumor DNA, in addition to the epigenome, genome, transcriptome (coding and noncoding), proteome (both conventional serum proteins and proteomic profiles) and metabolome. additional, it highlights the scientific purposes of circulating tumor cells for every melanoma sort and addresses the rising value of extracellular vesicular contents, together with miRNA, oncogenes and drug resistant elements. As such, it deals a invaluable reference advisor for melanoma researchers, oncologists, clinicians, surgeons, clinical scholars, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.

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Their study included patients with stage II and III melanomas who had liver metastasis (reviewed histories and hospital records of these patients). 0 %, respectively. 1 %, respectively. 9 months. The authors concluded that “monitoring of serum LDH can provide useful information in the postoperative follow-up of patients with melanoma” [73]. Serum LDH as Melanoma Prognostic and Treatment Response Biomarker LDH has also received attention as a prognostic and treatment response biomarker in patients with malignant melanoma.

1 %, respectively. 9 months. The authors concluded that “monitoring of serum LDH can provide useful information in the postoperative follow-up of patients with melanoma” [73]. Serum LDH as Melanoma Prognostic and Treatment Response Biomarker LDH has also received attention as a prognostic and treatment response biomarker in patients with malignant melanoma. In a retrospective study of metastatic melanoma, pretreatment LDH levels were significant independent predictor of survival [74]. Normal LDH in metastatic cancers also predicts good outcome [75].

Slipicevic A, Holm R, Nguyen MT, et al. Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. Am J Clin Pathol. 2005;124:528–36. 4. Stahl JM, Cheung M, Sharma A, et al. Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res. 2003;63:2881–90. 5. Wu H, Goel V, Haluska FG. PTEN signaling pathways in melanoma. Oncogene. 2003;22:3113–22. 6. Tsao H, Goel V, Wu H, et al. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.

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Cancer Biomarkers in Body Fluids: Biomarkers in Circulation by Gabriel D. Dakubo


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