Download e-book for iPad: Biological Response Modifiers in Human Oncology and by Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven

By Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)

ISBN-10: 1475714106

ISBN-13: 9781475714104

ISBN-10: 1475714122

ISBN-13: 9781475714128

The subject of organic reaction modifiers has attracted the eye of many biomedical investigators, together with immunologists, oncologists, pharmacologists, microbiologists, and biochemists, in addition to medical practitioners of drugs. This has happened customarily end result of the consciousness that the complicated procedure of mobile and humoral interactions culminating in a effective immune reaction is less than beautiful regulatory keep watch over for regular immune responses and that lack of keep watch over might markedly impact the potential of a number to reply in a effective demeanour to the various immunologic "insults" encountered within the setting. in addition, organic reaction amendment is taken into account through many to be a typical offshoot of the particularly new software of "immunotherapy" to melanoma. it's widely known that "immunotherapy" used to be practiced on the finish of the final century and the start of this century whilst it was once well-known that microbial infections have been attributable to specific species of micro organism and that passive management of serum con­ taining antibody to those microbes or their items may well, in lots of instances, favorably effect the end result of an infectious process.

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Rationale for phase 1 monoclonal antibody (MoAb) serotherapy trials. 1. Determine toxicity of MoAb serotherapy in carefully monitored dose escalation trials. 2. Determine optimal dosage with reference to toxicity, and biological effects. 3. Determine clinical response to MoAb therapy. 4. Determine immune response to murine MoAb. 5. All of the above are essential preliminary data on MoAb prior to use of MoAb conjugated to drugs and toxins. with most circulating T cells (examples would be TlOl and anti-Leu-l antibodies with the specificities shown in Table 2).

1982. Expression of human immune interferon eDNA in ~ coli and monkey cells. Nature 295: 503-508. 8. , and K. H. Fantes. 1980. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon. Nature 287: 408-411. 9. Harkins, R. , P. E. Hass, W. H. Kohr, B. B. Aggarwal, P. K. Week, and S. Apperson. 1982. Structural and biological properties of purified bacteria derived human fibroblast interferon. Proc. Natl. Acad. Sci. (in press). 10. Shepard, H. , D. Leung, N. Stebbing, and D.

Pazin. G. , M. Ho, H. Hoverkos, J. A. Armstrong, M. Breinig, H. Wechsler, A. Arvin, T. Merigan and K. Panteu. 1982. Effects of interferon-alpha on human warts. J. Interferon Res. 2: 235-244. 1981. Personal communication. INTERFERONS: SEVERAL QUESTIONS AND FEW ANSWERS 21 22. Strander, H. 1982. 3rd Annual International Congress for Interferon Research, Miami, Florida, November 1982. 23. Strander, H. 1977. Administration of exogenous interferon into patients with neoplastic diseases. Fifth Aharon KatzirKatcha1sky Conference.

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Biological Response Modifiers in Human Oncology and Immunology by Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)

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