By Paul G. Higgs
Within the present period of whole genome sequencing, Bioinformatics and Molecular Evolution presents an up to date and complete advent to bioinformatics within the context of evolutionary biology.
This available textual content:
- provides an intensive exam of series research, organic databases, development attractiveness, and purposes to genomics, microarrays, and proteomics
- emphasizes the theoretical and statistical equipment utilized in bioinformatics courses in a manner that's obtainable to organic technological know-how students
- places bioinformatics within the context of evolutionary biology, together with inhabitants genetics, molecular evolution, molecular phylogenetics, and their applications
- features end-of-chapter difficulties and self-tests to assist scholars synthesize the fabrics and observe their understanding
- is observed by means of a devoted site - www.blackwellpublishing.com/higgs - containing downloadable sequences, hyperlinks to net assets, solutions to self-test questions, and all paintings in downloadable layout (artwork additionally to be had to teachers on CD-ROM).
This very important textbook will equip readers with an intensive realizing of the quantitative tools utilized in the research of molecular evolution, and should be crucial analyzing for complicated undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics classes.
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Additional info for Bioinformatics and Molecular Evolution
As with all conjectures related to the origin of life and very early evolution, however, it is difficult to prove that an RNA world once existed. 1, we have many protein sequences for which experimentally determined three-dimensional structures are unavailable. A long-standing goal of bioinformatics has been to predict protein structure from sequence. Some methods for doing this will be discussed in Chapter 10 on pattern recognition. In this section, we will introduce some of the physico-chemical properties that are thought to be important for determining the way a protein folds.
7(c)). In bacteria, the small subunit contains the small subunit ribosomal RNA (SSU rRNA), which is typically 1500 nucleotides long, together with about 20 ribosomal proteins. The large subunit contains large subunit ribosomal RNA (LSU rRNA), which is typically 3000 nucleotides long, together with about 30 proteins and another smaller ribosomal RNA known as 5S rRNA. The ribosomes of eukaryotes are larger – the two major rRNA molecules are significantly longer and the number of proteins in each subunit is greater.
There is a significant variation in volume between the amino acids. 4 times the volume of the smallest amino acid, glycine. Creighton (1993) gives more information on van der Waals interactions and on amino acid volumes. 2 Physico-chemical properties of the amino acids. Alanine Arginine Asparagine Aspartic acid Cysteine Glutamine Glutamic acid Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine Mean Std. dev. Ala Arg Asn Asp Cys Gln Glu Gly His Ile Leu Lys Met Phe Pro Ser Thr Trp Tyr Val A R N D C Q E G H I L K M F P S T W Y V Vol.
Bioinformatics and Molecular Evolution by Paul G. Higgs