By Klaus-Michael Debatin, Simone Fulda, Editors
Right here, a world and hugely distinct group of authors leads readers from the foundations of programmed mobilephone loss of life to the position of apoptosis in melanoma improvement and rising therapy techniques. Divided into specific elements, the 1st specializes in apoptosis signaling, masking extensive such subject matters as mitochondria, effector platforms, the Bcl-2 kinfolk, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. the second one part is going directly to study apoptosis in melanoma and melanoma remedy, with a close examine version platforms, molecular prognosis, mobile tension, DNA harm and service, molecular pursuits and healing points. With its powerful concentrate on fresh advancements in melanoma treatment, this ebook is geared toward oncologists, molecular and phone biologists, biochemists, and people operating within the pharmaceutical and biotechnological industries.
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Additional resources for Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts
An imbalance between apoptosis and proliferation can result in tumor formation. These imbalances are capable of increasing tumor size and can also render the tumor resistant towards therapy. As death receptor (DR) signaling contributes to efficiency of cancer therapy, insights into the signaling cascades of DRs may provide new strategies for drug development. 1 Introduction Cell death is a key event in biology. At least two modes of cell death can be distinguished: necrosis and apoptosis (programmed cell death) .
However, attempts to induce CD95L expression on tumor cells resulted in tumor rejection [113, 114]. 3 Cancer and CD95/CD95L System has also been observed . At present, a number of contradictory studies exist in the literature. Thus, it has to be stated that, despite the doubtless attraction of a “tumor counterattack” hypothesis, so far no study has conclusively demonstrated its relevance for an in vivo situation. g. transforming growth factor (TGF)-b . 2 Angiogenesis New blood vessel formation is a prerequisite for malignant tumor progression and metastasis.
Thus, it seems reasonable to conclude that in cells that can induce CD95/ CD95L signaling, drug-induced apoptosis may include cell death mechanism analogous to AICD of T cells. Nevertheless, despite the body of evidence suggesting an involvement of the CD95/CD95L system in drug-induced apoptosis, the proposed mechanism has been challenged by a number of other studies [132–137]. 3 Cancer and CD95/CD95L System not confer protection to chemotherapy-induced apoptosis [133, 136, 137]. Cytotoxic drug-induced cell death was not alleviated by enforced expression of FLIP and DN-FADD despite clear inhibition of caspase-8 activity.
Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts by Klaus-Michael Debatin, Simone Fulda, Editors