Download PDF by Waldemar Priebe: Anthracycline Antibiotics. New Analogues, Methods of

By Waldemar Priebe

ISBN-10: 0841214956

ISBN-13: 9780841214958

ISBN-10: 0841230404

ISBN-13: 9780841230408

content material: Unresolved structure-activity relationships in anthracycline analogue improvement / Edward M. Acton --
Non-cross-resistant anthracyclines with diminished basicity and elevated balance of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler --
Fluorinated anthracyclinones and their glycosylated items / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone --
Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek --
man made concepts for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch --
Synthesis and organic actions of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi --
Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano --
Synthesis of anthraquinone analogues of associated anthracycline / Ping Ge and Richard A. Russell --
Synthesis and learn of structure-activity relationships of recent periods of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi --
Molecular attractiveness of DNA by means of daunorubicin / Jonathan B. Chaires --
Adducts of DNA and anthracycline antibiotics : constructions, interactions, and actions / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang --
DNA topoisomerases and their inhibition via anthracyclines / Yves Pommier --
Anthracycline antihelicase motion : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas --
Membrane biophysical parameters influencing anthracycline motion / Ratna Mehta and Thomas G. Burke --
sign transduction platforms in doxorubicin hydrochloride mechanism of motion / Paul Vichi, James tune, Jean Hess, and Thomas R. Tritton --
research of multidrug transporter in dwelling cells : program to uptake and free up of anthracycline derivatives by way of drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo --
position of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow --
Amelioration of anthracycline-induced cardiotoxicity by way of natural chemical substances / Donald T. Witiak and Eugene H. Herman --
Use of drug companies to ameliorate the healing index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe.

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Extra info for Anthracycline Antibiotics. New Analogues, Methods of Delivery, and Mechanisms of Action

Example text

Idarubicin itself is a powerful antileukemic anthracycline recently introduced into therapeutic use worldwide (4). The fluorine atom was introduced onto the idarubicin aglycone, idarubicinone, starting from epoxyketone 16a (as a racemic compound). Similarly, the corresponding derivative in the natural (daunorubicin) series was obtained starting from 16b (in the optically active form). The two compounds were therefore chosen as intermediates for the synthesis of 8-(S)-fluoro-anthracyclines 17a and 17b.

Friedman, R. A. ; Manning, G. Biopolymers 1984, 23, 2671. ; Wright, H . ; Sweatman, T. ; Israel, M . Oncol. Res. 1992, 4, 343. ; Sweatman, T. ; Docter, M . ; Israel, M . Cancer Res. 1992, 52, 3409. ; Burke, T. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-30, Denver, 1993. ; Sweatman, T. ; Dockter, M . ; Priebe, W. Oncol. Res. 1993, 5, 229. , In Anthracycline Antibiotics; El Khadem, H . : New York, 1982, p. 197. ; Zamojski, A. Tetrahedron 1980, 36, 287. ; Neamati, N . ; Perez-Soler, R. Tetrahedron Lett.

New York, 1982, p. 197. ; Zamojski, A. Tetrahedron 1980, 36, 287. ; Neamati, N . ; Perez-Soler, R. Tetrahedron Lett. 1991, 32, 3313. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-22, San Francisco, 1980. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-11, New York, 1981. ; Varela, O. Abstr. Pap. XIth Internat. Carbohydr. Symp. Vancouver, 1982. Naff, M . ; Narayanan, V. , In Anthracycline Antibiotics; El Khadem, H . ; Academic Press, Inc: New York, 1982, p. 1. ; Wolgemuth, R. L. Eur. Pat. 1984, EP116,222, August 22.

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Anthracycline Antibiotics. New Analogues, Methods of Delivery, and Mechanisms of Action by Waldemar Priebe

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