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7 µM against C. neoformans, respectively. These data suggest that the presence of the hydroxyl group in fluconazole is critical for generating maximal antifungal activities. MEDI 61 Optimizing the synthesis of N-methanocarbathymidine, a potent and selective antiviral agent Victor E. gov, and Olaf R. 0]hexane template locked in the northern conformation. Nucleosides based on this scaffold were originally introduced to investigate the conformational preferences of kinases and polymerases. However, some conformationally restricted nucleosides also showed interesting antiviral properties.

However, the biological potency of 1 is limited by accompanying cytotoxity due to formation of the corresponding 5'-nucleotides. To circumvent this, 5'fluoro-5'-deoxyaristeromycin (2) attracted our interest. The synthesis and antiviral properties 2 will be presented. This research was supported by funds from the Department of Health and Human Services (AI 56540). MEDI 80 4'-Fluoro analog of 5'-noraristeromycin Weikuan Li1, Xueqiang Yin2, and Stewart W. Schneller2. (1) Auburn University, 179 Chemistry Building, Auburn University, Auburn, AL AL, (2) Department of Chemistry and Biochemistry, Auburn University Carbocyclic nucleoside analogs have been significant to antiviral agent design and biomedical investigations.

Considering the limitations of delivering radiosensitization agents to human tumors, this study provide insights into the structural modifications needed to enhance the bioavailability of such compounds. This research was supported by grant no. edu The estrogen receptor (ER) is a particularly attractive target in the treatment of breast cancer and the development of receptor-based breast cancer imaging agents for use in biomedical imaging technique positron emission tomography (PET). Cyclofenil derivatives have high binding affinity to ER, often comparable to or greater than that of estradiol, a well-known ER ligand.

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Abstracts-233rd ACS National Meeting by ACS

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