By Pradyot Patnaik
The definitive consultant to the damaging houses of chemical compounds
Correlating chemical constitution with toxicity to people and the surroundings, and the chemical constitution of compounds to their harmful houses, A entire consultant to the dangerous houses of chemicals, 3rd Edition permits clients to evaluate the toxicity of a substance even if no experimental facts exists. therefore, it bridges the space among dangerous fabrics and chemistry. commonly up to date and improved, this reference:
- Examines organics, metals and inorganics, commercial solvents, universal gases, particulates, explosives, and radioactive ingredients, protecting every thing from toxicity and carcinogenicity to flammability and explosive reactivity to dealing with and disposal practices
- Arranges detrimental chemicals in keeping with their chemical buildings and practical teams for simple reference
- Includes up to date info at the poisonous, flammable, and explosive houses of chemical substances
- Covers extra metals within the chapters on poisonous and reactive metals
- Updates the brink publicity limits within the office air for a couple of substances
- Features the newest details on commercial solvents and poisonous and flammable gases
- Includes a variety of tables, formulation, and a thesaurus for fast reference
since it presents details that permits people with a chemistry heritage to accomplish checks with no previous information, this accomplished reference appeals to chemists, chemical engineers, toxicologists, and forensic scientists, in addition to commercial hygienists, occupational physicians, Hazmat pros, and others in similar fields.
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Extra info for A comprehensive guide to the hazardous properties of chemical substances
A chemical is distributed rapidly throughout the body, after it enters the bloodstream. The extent to which it enters into an organ depends on the blood ﬂow, the ease of its diffusion through the local capillary wall and the cell membrane, and the afﬁnity for the chemical. A chemical can bind in a tissue or organ. Such binding can result in its accumulation or higher concentration in the tissue. If it is bound strongly, by irreversible covalent bonding, the effect can be signiﬁcantly toxic. However, a number of substances, as well as a major portion of the dose, undergo weak noncovalent binding that is reversible.
The toxic properties of chemicals may be assessed in a very general way from two relationships: the dose-response relationship and the structure –activity relationship (SAR). The toxicity depends greatly on the dose — the amount of substance per unit of body weight to which an organism is exposed. The effect on the organism is known as response. Thus, at a very low level, a highly toxic compound can be harmless. On the other hand, a substance with relatively very low toxicity can cause severe adverse effects when taken in large doses.
Paresthesia An abnormal sensation, as burning or prickling. Photophobia Abnormal visual intolerance to light. Phytotoxic Poisonous to plants, inhibiting plant growth. Pulmonary Pertaining to the lungs. Pulmonary edema Excess ﬂuid in the lungs, caused by irritants that injure the pulmonary epithelium. Such conditions can affect oxygen uptake, causing death. Receptor Binding site that has a high afﬁnity for a particular ligand. Receptors interact with biologically endogenous ligands, facilitating intracellular communication.
A comprehensive guide to the hazardous properties of chemical substances by Pradyot Patnaik